1887

Abstract

SUMMARY: A strain of from Campine forest soil was found to secrete an antibiotic, for which the name Ramycin is proposed. It is especially active against Gram-positive micro-organisms and H37Rv, but sensitive organisms quickly acquire resistance to it. Although it is not very toxic, it possesses a necrotic action on tissues. Ramycin can protect mice against streptococcal and staphylococcal infections but not against H37Rv.

Ramycin crystallizes in orthorhombic plates. The new antibiotic is an optically-inactive unsaturated hydroxy acid, containing C, H and O only.

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/content/journal/micro/10.1099/00221287-18-2-377
1958-04-01
2021-08-04
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References

  1. Brian P. W. 1951; Antibiotics produced by fungi. Bot. Rev 17:6
    [Google Scholar]
  2. De Somer P., Van Dijck P. 1955; A preliminary report on antibiotic number 899, a streptogramin-like substance. Antibiot. Chemother 5:11
    [Google Scholar]
  3. Jefferys E. G., Brian P. W., Hemming H. G., Lowe D. 1953; Antibiotic production by the microfungi of acid heath soils. J. gen. Microbiol 9:314
    [Google Scholar]
  4. Miller B. M., Porter CL. 1956–7; Nature of Antibiotics manifested by selected species of Mueorales. Antibiot. Ann
    [Google Scholar]
  5. Naumov N. A., Buchet S., Mouraviev I. 1939 Encyclopédic Mycologique. IX. Clés des Mucorinées Ed Paul Lechevalier, Paris VIe:
    [Google Scholar]
  6. Robbins W. J., Hervey A., Ross W. D., Roberta MA., Robbins W. C. 1945; A survey of some wood-destroying and other fungi for antibacterial activity. Bull. Torrey Bot. Cl 72:165
    [Google Scholar]
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