Optical Activity of Amino Acids Formed by Reductive Amination in Free

Abstract

SUMMARY: Suspensions of form -alanine when incubated with pyruvate and ammonia. When leucine and valine are formed from the analogous keto acids, only the -isomer is found. Since has a racemase active for alanine but not for valine or leucine, it is possible that the -alanine may be the primary product and which is then racemized.

Suspensions of and of some other organisms can synthesize certain amino acids from ammonia and the corresponding keto-acids (Fair-hurst, King & Sewell, 1956). When alanine is formed from pyruvate by , the racemic -mixture is produced. The present paper gives evidence in support of this finding (mentioned by Fairhurst . 1956, but not in detail) and discusses the mechanism of the reaction.

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/content/journal/micro/10.1099/00221287-17-3-620
1957-12-01
2024-03-29
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