SUMMARY: Sixty Streptomyces isolates which produce polyene antibiotics were isolated from 25 soil samples collected in different parts of the world. Of these isolates 25 produced tetraenes, 23 produced pentaenes, 1 produced a hexaene, and 15 produced heptaenes. One isolate produced simultaneously a tetraene and a pentaene, another produced a tetraene and a heptaene, and a third produced a tetraene, a pentaene and a heptaene. The antibiotics showed activity against a wide range of fungi; the minimum inhibitory concentrations against and are given for 10 of them. The distribution of activity between culture filtrate and mycelium is given for 14 of the antibiotics.


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