1887

Abstract

SUMMARY: Cephalosporin C, a hydrophilic, penicillin-like antibiotic which is insensitive to penicillinase, is much less active than benzylpenicillin against the Oxford strain of but much more active than benzylpenicillin against a penicillinase-producing strain of (D3R). When used together, cephalosporin C and benzylpenicillin act synergistically against strain D3R presumably because cephalosporin C is a competitive inhibitor of penicillinase. When grown under certain conditions in the presence of cephalosporin C, benzylpenicillin, or bacitracin, the Oxford staphylococcus gives rise during a single culture to a resistant bacterial population consisting largely or partly of Gram-negative bacilli. In the presence of bacitracin a similar change also occurs with strain D3R.

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/content/journal/micro/10.1099/00221287-16-3-604
1957-06-01
2022-09-25
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References

  1. Abraham E. P., Heatley N. G., Brookes P., Fuller A. T., Walker J. 1956; Probable identity of an antibiotic produced by a spore-bearing bacillus of the B. pumilus group with micrococcin. Nature; Lond: 17844
    [Google Scholar]
  2. Abraham E. P., Newton G. G. F. 1956a; Experiments on the degradation of cephalosporin C. Biochem. J 62658
    [Google Scholar]
  3. Abraham E. P., Newton G. G. F. 1956b; A comparison of the action of penicillinase on benzylpenicillin and cephalosporin N and the competitive inhibition of penicillinase by cephalosporin C. Biochem. J 63628
    [Google Scholar]
  4. Abraham E. P., Newton G. G. F., Crawford K., Burton H. S., Hale C. W. 1953; Cephalosporin N: a new type of penicillin. Nature; Lond: 171343
    [Google Scholar]
  5. Abraham E. P., Newton G. G. F., Hale C. W. 1954; Purification and some properties of cephalosporin N, a new penicillin. Biochem. J 58:94
    [Google Scholar]
  6. Abraham E. P., Olson B. H., Newton G. G. F., Schurmans D. M., Schenck J. R., Fisher M. W., Hargie M. P., Fusari S. A. 1955; Identity of cephalosporin N and synnematin B. Nature; Lond: 176551
    [Google Scholar]
  7. Barnes E. M. 1955; Bacterial growth on heart digest media in relation to the trypsin preparation used. J. appl. Bact 18:45
    [Google Scholar]
  8. Briggs S., Crawford K., Abraham E. P., Gladstone G. P. 1957; Some properties of Gram-negative bacilli obtained from a strain of Staphylococcus aureus in the presence of benzylpenicillin. J. gen. Microbiol 16:614
    [Google Scholar]
  9. Brookes P., Fuller A. T., Walker J. 1957; The chemistry of micrococcin P. Part 1. J. chem. Soc p. 689
    [Google Scholar]
  10. Eagle H., Saz A. K. 1955; Antibiotics. Annu. Rev. Microbiol 9:173
    [Google Scholar]
  11. Florey H. W. 1955; Antibiotic products of a versatile fungus. Ann. intern. Med 43:480
    [Google Scholar]
  12. Florey H. W. 1957; The medical aspects of the development of resistance to antibiotics. First European Symposium on Antibiotics, Milan. G. Microb in the Press
    [Google Scholar]
  13. Gale E. F., Folkes J. P. 1953; The assimilation of amino acids by bacteria. Biochem. J 55:721
    [Google Scholar]
  14. Hausmann W., Weisiger J. R., Craig L. C. 1955; Partial hydrolysis studies with bacitracin. J. Amer. chem. Soc 77:721
    [Google Scholar]
  15. Heatley N. G., Doery H. M. 1951; The preparation and some properties of purified micrococcin. Biochem. J 50:247
    [Google Scholar]
  16. Kay D., Fildes P. 1950; The calcium requirements of a typhoid bacteriophage. Brit. J. exp. Path 31:338
    [Google Scholar]
  17. Klimek J. W., Cavallito C. J., Bailey J. H. 1948; Induced resistance of Staphylococcus aureus to various antibiotics. J. Bact 55:139
    [Google Scholar]
  18. Lockhart I. M., Abraham E. P., Newton G. G. F. 1955; The N-terminal and sulphur-containing residues of bacitracin A. Biochem. J 61:534
    [Google Scholar]
  19. Newton G. G. F., Abraham E. P. 1954; Degradation, structure and some derivatives of cephalosporin N. Biochem. J 58:103
    [Google Scholar]
  20. Newton G. G. F., Abraham E. P. 1956; Isolation of cephalosporin C, a penicillin-like antibiotic containing D-α-aminoadipic acid. Biochem. J 62:651
    [Google Scholar]
  21. Paine T. F. 1951; The similarity in action of bacitracin and penicillin on the staphylococcus. J. Bact 61:259
    [Google Scholar]
  22. Pollock M. R. 1957; The activity and specificity of inducers of penicillinase production in Bacillus cereus NRRL 569. Biochem. J in the Press
    [Google Scholar]
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