SUMMARY: Cephalosporin C, a hydrophilic, penicillin-like antibiotic which is insensitive to penicillinase, is much less active than benzylpenicillin against the Oxford strain of but much more active than benzylpenicillin against a penicillinase-producing strain of (D3R). When used together, cephalosporin C and benzylpenicillin act synergistically against strain D3R , pzesumably because cephalosporin C is a competitive inhibitor of penicillinase. When grown under certain conditions in the presence of cephalosporin C. benzyl-penicillin, or bacitracin, the Oxford staphylococcus gives rise during a single culture to a resistant bacterial population consisting largely or partly of Gram-negative bacilli. In the presence of bacitracin a similar change also occurs with strain D3R.


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