SUMMARY: The formation of pyocyanine by resting was studied. Glutamic acid was found to be a good substrate for this synthesis and could be replaced by several related amino acids (γ-aminobutyric acid, pyrrolidone-carboxylic acid, glutamine, aspartic acid, proline, hydroxyproline, arginine, histidine, alanine), and by some organic acids active in the tricarboxylic acid cycle (succinate, fumarate, pyruvate) when added together with ammonium ions. Magnesium ions were essential for pyocyanine synthesis and could not be replaced by other metals tested (Co, Fe). Pyocyanine formation was inhibited specifically by respiratory poisons (KCN, NaN); NaF, on the other hand, was not inhibitory.


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