SUMMARY: A strain of has been found under certain conditions to liberate a bacteriocin-like agent which has been termed ‘megacin’. The conditions necessary for induction of megacin formation in this strain are reminiscent of those leading to induction of bacteriophage in other (lysogenic) strains of the same species. Megacin, however, differs from bacteriophage in not giving rise to any further production of antibacterial principle, after acting on bacterial cells. Induction of megacin formation by ultraviolet irradiation is dependent on the composition of the medium. Only in a complete medium is megacin produced, although certain preliminary stages in the induction process and a concomitant, reversible photobiological effect can take place in minimal nutrient medium.


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