SUMMARY: Two loci which affect the production of penicillin by have been identified. Capacity to produce penicillin is suppressed by eight mutant alleles at one of the loci, and a marked decrease of yield accompanied by an effect on conidium colour is produced by one mutant allele at the other locus. The two loci are on different chromosomes. The wild type alleles of the two genes restore penicillin production in the heterokaryotic and heterozygous conditions but not when they are carried in different mycelia in mixed culture. Haploid and diploid strains have been identified among the segregants from a heterozygous diploid.


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