1887

Abstract

Numerous chitin synthase structural () genes have been identified in fungi, and usually there are several genes per species. Compensatory expression of one gene in response to defects in other genes has not been reported. Five chitin synthase structural () genes have been identified in the melanized human pathogen : , , , and . This study showed that increased expression existed as a compensatory mechanism in response to stress induced by chitin synthase gene disruptions, or by exposure of the wild-type or two temperature-sensitive morphological mutants, for short or long periods, to 37 °C. In general, the compensatory responses varied with each gene, and in accordance with the hypothesized functions of the chitin synthase (WdChsp) encoded. It is suggested that these compensatory responses indicate that gene transcription in functions as part of a cell-wall integrity pathway in a manner similar to that recently described for .

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2002-09-01
2020-01-19
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