1887

Abstract

The nucleotide sequence of the 12·6 kb region between the and genes of serovar Typhimurium LT2 () was compared to other enteric bacterial intergenic regions. The region is composed of three distinct segments, designated HK, O and S, as defined by sequence similarities to contiguous ORFs in other bacteria. Inverted chromosomal orientations of each of these segments are found between the and genes in related . The HK segment is distantly related to a cluster of seven ORFs found in and a cluster of five ORFs found between the and genes in K-12. The O segment is related to the intergenic region found in O157:H7 and type 1. The third segment, S, is common to diverse species, but is absent from . Despite the extensive collinearity and conservation of the overall genetic maps of and K-12, the insertions, deletions and inversions in the region provide evidence that this region of the chromosome is an active site for horizontal gene transfer and rearrangement.

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2002-08-01
2020-09-30
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