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Keyword(s): actin , Cdc42 , Map , phosphorylation and signalling
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2002-07-01
2024-10-03
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References

  1. Abe A., de Grado M., Pfuetzner R. A., Sánchez-SanMartı́n C., DeVinney R., Puente J. L., Strynadka N. C. J., Finlay B. B. 1999; Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretion. Mol Microbiol 33:1162–1175
    [Google Scholar]
  2. Abul-Milh M., Wu Y., Lau B., Lingwood C. A., Foster D. B. 2001; Induction of epithelial cell death including apoptosis by enteropathogenic Escherichia coli expressing bundle-forming pili. Infect Immun 69:7356–7364 [CrossRef]
    [Google Scholar]
  3. Barnett Foster D., Abul-Milh M., Huesca M., Lingwood C. A. 2000; Enterohemorrhagic Escherichia coli induces apoptosis which augments bacterial binding and phosphatidylethanolamine exposure on the plasma membrane outer leaflet. Infect Immun 68:3108–3115 [CrossRef]
    [Google Scholar]
  4. Batchelor M., Prasannan S., Daniell S., Reece S., Connerton I., Bloomberg G., Dougan G., Frankel G., Matthews S. 2000; Structural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenic Escherichia coli . EMBO J 19:2452–2464 [CrossRef]
    [Google Scholar]
  5. Bishop A. L., Hall A. 2000; Rho GTPases and their effector proteins. Biochem J 348:241–255 [CrossRef]
    [Google Scholar]
  6. Boya P., Roques B., Kroemer G. 2001; New EMBO members’ review: viral and bacterial proteins regulating apoptosis at the mitochondrial level. EMBO J 20:4325–4331 [CrossRef]
    [Google Scholar]
  7. Cantarelli V. V., Takahashi A., Yanagihara I., Akeda Y., Imura K., Kodama T., Kono G., Sato Y., Honda T. 2001; Talin, a host cell protein, interacts directly with the translocated intimin receptor, Tir, of enteropathogenic Escherichia coli , and is essential for pedestal formation. Cell Microbiol 3:745–751 [CrossRef]
    [Google Scholar]
  8. Crane J. K., Majumdar S., Pickhardt D. F. 3rd (1999; Host cell death due to enteropathogenic Escherichia coli has features of apoptosis. Infect Immun 67:2575–2584
    [Google Scholar]
  9. Daniell S. J., Delahay R. M., Shaw R. K., Hartland E. L., Pallen M. J., Booy F., Ebel F., Knutton S., Frankel G. 2001; Coiled-coil domain of enteropathogenic Escherichia coli type III secreted protein EspD is involved in EspA filament-mediated cell attachment and hemolysis. Infect Immun 69:4055–4064 [CrossRef]
    [Google Scholar]
  10. de Grado M., Abe A., Gauthier A., Steele-Mortimer O., DeVinney R., Finlay B. B. 1999; Identification of the intimin-binding domain of Tir of enteropathogenic Escherichia coli . Cell Microbiol 1:7–17 [CrossRef]
    [Google Scholar]
  11. DeVinney R., Stein M., Reinscheid D., Abe A., Ruschkowski S., Finlay B. B. 1999; Enterohemorrhagic Escherichia coli O157: H7 produces Tir, which is translocated to the host cell membrane but is not tyrosine phosphorylated. Infect Immun 67:2389–2398
    [Google Scholar]
  12. DeVinney R., Nisan I., Ruschkowski S., Rosenshine I., Finlay B. B. 2001; Tir tyrosine phosphorylation and pedestal formation are delayed in enteropathogenic Escherichia coli sep Z:: TnphoA mutant 30-5-1(3. Infect Immun 69:559–563 [CrossRef]
    [Google Scholar]
  13. Donnenberg M. S., Calderwood S. B., Donohue-Rolfe A., Keusch G. T., Kaper J. B. 1990; Construction and analysis of TnphoA mutants of enteropathogenic Escherichia coli unable to invade HEp-2 cells. Infect Immun 58:1565–1571
    [Google Scholar]
  14. Donnenberg M. S., Tacket C. O., James S. P., Losonsky G., Nataro J. P., Wasserman S. S., Kaper J. B., Levine M. M. 1993; Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection. J Clin Investig 92:1412–1417 [CrossRef]
    [Google Scholar]
  15. Elliott S. J., Wainwright L. A., McDaniel T. K., Jarvis K. G., Deng Y. K., Lai L. C., McNamara B. P., Donnenberg M. S., Kaper J. B. 1998; The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69. Mol Microbiol 28:1–4
    [Google Scholar]
  16. Elliott S. J., Yu J., Kaper J. B. 1999a; The cloned locus of enterocyte effacement from enterohemorrhagic Escherichia coli O157: H7 is unable to confer the attaching and effacing phenotype upon E. coli K-12. Infect Immun 67:4260–4263
    [Google Scholar]
  17. Elliott S. J., Hutcheson S. W., Dubois M. S., Mellies J. L., Wainwright L. A., Batchelor M., Frankel G., Knutton S., Kaper J. B. 1999b; Identification of CesT, a chaperone for the type III secretion of Tir in enteropathogenic Escherichia coli . Mol Microbiol 33:1176–1189
    [Google Scholar]
  18. Elliott S. J., Krejany E. O., Mellies J. L., Robins-Browne R. M., Sasakawa C., Kaper J. B. 2001; EspG, a novel type III system-secreted protein from enteropathogenic Escherichia coli with similarities to VirA of Shigella flexneri . Infect Immun 69:4027–4033 [CrossRef]
    [Google Scholar]
  19. Erickson J. W., Cerione R. A. 2001; Multiple roles for Cdc42 in cell regulation. Curr Opin Cell Biol 13:153–157 [CrossRef]
    [Google Scholar]
  20. Feliciello A., Gottesman M. E., Avvedimento E. V. 2001; The biological functions of A-kinase anchor proteins. J Mol Biol 308:99–114 [CrossRef]
    [Google Scholar]
  21. Finlay B. B., Rosenshine I., Donnenberg M. S., Kaper J. B. 1992; Cytoskeletal composition of attaching and effacing lesions associated with enteropathogenic Escherichia coli adherence to HeLa cells. Infect Immun 60:2541–2543
    [Google Scholar]
  22. Frankel G., Phillips A. D., Rosenshine I., Dougan G., Kaper J. B., Knutton S. 1998; Enteropathogenic and enterohaemorrhagic Escherichia coli : more subversive elements. Mol Microbiol 30:911–921 [CrossRef]
    [Google Scholar]
  23. Freeman N. L., Zurawski D. V., Chowrashi P., Ayoob J. C., Huang L., Mittal B., Sanger J. M., Sanger J. W. 2000; Interaction of the enteropathogenic Escherichia coli protein, translocated intimin receptor (Tir), with focal adhesion proteins. Cell Motil Cytoskelet 47:307–318 [CrossRef]
    [Google Scholar]
  24. Friebel A., Ilchmann H., Aepfelbacher M., Ehrbar K., Machleidt W., Hardt W. D. 2001; SopE and SopE2 from Salmonella typhimurium activate different sets of RhoGTPases of the host cell. J Biol Chem 276:34035–34040 [CrossRef]
    [Google Scholar]
  25. Friedberg D., Umanski T., Fang Y., Rosenshine I. 1999; Hierarchy in the expression of the locus of enterocyte effacement genes of enteropathogenic Escherichia coli . Mol Microbiol 34:941–952 [CrossRef]
    [Google Scholar]
  26. Goosney D. L., Gruenheid S., Finlay B. B. 2000a; Gut feelings: enteropathogenic E. coli (EPEC) interactions with the host. Annu Rev Cell Dev Biol 16:173–189 [CrossRef]
    [Google Scholar]
  27. Goosney D. L., DeVinney R., Pfuetzner R. A., Frey E. A., Strynadka N. C., Finlay B. B. 2000b; Enteropathogenic E. coli translocated intimin receptor, Tir, interacts directly with alpha-actinin. Curr Biol 10:735–738 [CrossRef]
    [Google Scholar]
  28. Goosney D. L., DeVinney R., Finlay B. B. 2001; Recruitment of cytoskeletal and signaling proteins to enteropathogenic and enterohemorrhagic Escherichia coli pedestals. Infect Immun 69:3315–3322 [CrossRef]
    [Google Scholar]
  29. Gruenheid S., DeVinney R., Bladt F., Goosney D., Gelkop S., Gish G. D., Pawson T., Finlay B. B. 2001; Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells. Nat Cell Biol 3:856–859 [CrossRef]
    [Google Scholar]
  30. Hall A. 1998; Rho GTPases and the actin cytoskeleton. Science 279:509–514 [CrossRef]
    [Google Scholar]
  31. Hartland E. L., Batchelor M., Delahay R. M., Hale C., Matthews S., Dougan G., Knutton S., Connerton I., Frankel G. 1999; Binding of intimin from enteropathogenic Escherichia coli to Tir and to host cells. Mol Microbiol 32:151–158 [CrossRef]
    [Google Scholar]
  32. Heczko U., Carthy C. M., O’Brien B. A., Finlay B. B. 2001; Decreased apoptosis in the ileum and ileal Peyer’s patches: a feature after infection with rabbit enteropathogenic Escherichia coli O103. Infect Immun 69:4580–4589 [CrossRef]
    [Google Scholar]
  33. Hueck C. J. 1998; Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol Mol Biol Rev 62:379–433
    [Google Scholar]
  34. Ide T., Laarmann S., Greune L., Schillers H., Oberleithner H., Schmidt M. A. 2001; Characterization of translocation pores inserted into plasma membranes by type III-secreted Esp proteins of enteropathogenic Escherichia coli . Cell Microbiol 3:669–679 [CrossRef]
    [Google Scholar]
  35. Jarvis K. G., Giron J. A., Jerse A. E., McDaniel T. K., Donnenberg M. S., Kaper J. B. 1995; Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation. Proc Natl Acad Sci USA 92:7996–8000 [CrossRef]
    [Google Scholar]
  36. Jerse A. E., Yu J., Tall B. D., Kaper J. B. 1990; A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. Proc Natl Acad Sci USA 87:7839–7843 [CrossRef]
    [Google Scholar]
  37. Kalman D., Weiner O. D., Goosney D. L., Sedat J. W., Finlay B. B., Abo A., Bishop J. M. 1999; Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals. Nat Cell Biol 1:389–391 [CrossRef]
    [Google Scholar]
  38. Kaper J. B. 1998; EPEC delivers the goods. Trends Microbiol 6:169–172 [CrossRef]
    [Google Scholar]
  39. Kenny B. 1999; Phosphorylation of tyrosine 474 of the enteropathogenic Escherichia coli (EPEC) Tir receptor molecule is essential for actin nucleating activity and is preceded by additional host modifications. Mol Microbiol 31:1229–1241 [CrossRef]
    [Google Scholar]
  40. Kenny B. 2001; The enterohaemorrhagic Escherichia coli (serotype O157: H7) Tir molecule is not functionally interchangeable for its enteropathogenic E. coli (serotype O127:H6) homologue. Cell Microbiol 3:499–510 [CrossRef]
    [Google Scholar]
  41. Kenny B., Finlay B. B. 1995; Protein secretion by enteropathogenic Escherichia coli is essential for transducing signals to epithelial cells. Proc Natl Acad Sci USA 92:7991–7995 [CrossRef]
    [Google Scholar]
  42. Kenny B., Finlay B. B. 1997; Intimin-dependent binding of enteropathogenic Escherichia coli to host cells triggers novel signaling events, including tyrosine phosphorylation of phospholipase C gamma. Infect Immun 65:2528–2536
    [Google Scholar]
  43. Kenny B., Jepson M. 2000; Targeting of an enteropathogenic E. coli (EPEC) effector protein to host mitochondria. Cell Microbiol 2:579–590 [CrossRef]
    [Google Scholar]
  44. Kenny B., Warawa J. 2001; Enteropathogenic Escherichia coli (EPEC) Tir receptor molecule does not undergo full modification when introduced into host cells by EPEC-independent mechanisms. Infect Immun 69:1444–1453 [CrossRef]
    [Google Scholar]
  45. Kenny B., Lai L. C., Finlay B. B., Donnenberg M. S. 1996; EspA, a protein secreted by enteropathogenic Escherichia coli , is required to induce signals in epithelial cells. Mol Microbiol 20:313–323 [CrossRef]
    [Google Scholar]
  46. Kenny B., DeVinney R., Stein M., Reinscheid D. J., Frey E. A., Finlay B. B. 1997; Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell 91:511–520 [CrossRef]
    [Google Scholar]
  47. Kenny B., Ellis S., Leard A., Warawa J., Mellor H., Jepson M. A. 2002; Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic E. coli (EPEC) effector molecules. Mol Microbiol 44:1095–1107 [CrossRef]
    [Google Scholar]
  48. Knutton S., Lloyd D. R., McNeish A. S. 1987; Adhesion of enteropathogenic Escherichia coli to human intestinal enterocytes and cultured human intestinal mucosa. Infect Immun 55:69–77
    [Google Scholar]
  49. Knutton S., Baldwin T., Williams P. H., McNeish A. S. 1989; Actin accumulation at sites of bacterial adhesion to tissue culture cells: basis of a new diagnostic test for enteropathogenic and enterohemorrhagic Escherichia coli . Infect Immun 57:1290–1298
    [Google Scholar]
  50. Knutton S., Rosenshine I., Pallen M. J., Nisan I., Neves B. C., Bain C., Wolff C., Dougan G., Frankel G. 1998; A novel EspA-associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells. EMBO J 17:2166–2176 [CrossRef]
    [Google Scholar]
  51. Kubori T., Matsushima Y., Nakamura D., Uralil J., Lara-Tejero M., Sukhan A., Galan J. E., Aizawa S. I. 1998; Supramolecular structure of the Salmonella typhimurium type III protein secretion system. Science 280:602–605 [CrossRef]
    [Google Scholar]
  52. Luo Y., Frey E. A., Pfuetzner R. A., Creagh A. L., Knoechel D. G., Haynes C. A., Finlay B. B., Strynadka N. C. 2000; Crystal structure of enteropathogenic Escherichia coli intimin-receptor complex. Nature 405:1073–1077 [CrossRef]
    [Google Scholar]
  53. Marches O., Nougayrede J. P., Boullier S. 8 other authors 2000; Role of tir and intimin in the virulence of rabbit enteropathogenic Escherichia coli serotype O103: H2. Infect Immun 68:2171–2182 [CrossRef]
    [Google Scholar]
  54. McDaniel T. K., Kaper J. B. 1997; A cloned pathogenicity island from enteropathogenic Escherichia coli confers the attaching and effacing phenotype on E. coli K-12. Mol Microbiol 23:399–407 [CrossRef]
    [Google Scholar]
  55. McDaniel T. K., Jarvis K. G., Donnenberg M. S., Kaper J. B. 1995; A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens. Proc Natl Acad Sci USA 92:1664–1668 [CrossRef]
    [Google Scholar]
  56. McNamara B. P., Koutsouris A., O’Connell C. B., Nougayrede J. P., Donnenberg M. S., Hecht G. 2001; Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. J Clin Investig 107:621–629 [CrossRef]
    [Google Scholar]
  57. Moon H. W., Whipp S. C., Argenzio R. A., Levine M. M., Giannella R. A. 1983; Attaching and effacing activities of rabbit and human enteropathogenic Escherichia coli in pig and rabbit intestines. Infect Immun 41:1340–1351
    [Google Scholar]
  58. Nataro J. P., Kaper J. B. 1998; Diarrheagenic Escherichia coli . Clin Microbiol Rev 11:142–201
    [Google Scholar]
  59. Paton A. W., Manning P. A., Woodrow M. C., Paton J. C. 1998; Translocated intimin receptors (Tir) of Shiga-toxigenic Escherichia coli isolates belonging to serogroups O26, O111, and O157 react with sera from patients with hemolytic-uremic syndrome and exhibit marked sequence heterogeneity. Infect Immun 66:5580–5586
    [Google Scholar]
  60. Perna N. T., Mayhew G. F., Posfai G., Elliott S., Donnenberg M. S., Kaper J. B., Blattner F. R. 1998; Molecular evolution of a pathogenicity island from enterohemorrhagic Escherichia coli O157: H7. Infect Immun 66:3810–3817
    [Google Scholar]
  61. Perna N. T., Plunkett G. 3rd, Burland V. 25 other authors 2001; Genome sequence of enterohaemorrhagic Escherichia coli O157: H7. Nature 409:529–533 [CrossRef]
    [Google Scholar]
  62. Rosenshine I., Donnenberg M. S., Kaper J. B., Finlay B. B. 1992; Signal transduction between enteropathogenic Escherichia coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake. EMBO J 11:3551–3560
    [Google Scholar]
  63. Rosenshine I., Ruschkowski S., Stein M., Reinscheid D. J., Mills S. D., Finlay B. B. 1996; A pathogenic bacterium triggers epithelial signals to form a functional bacterial receptor that mediates actin pseudopod formation. EMBO J 15:2613–2624
    [Google Scholar]
  64. Scheffzek K., Ahmadian M. R., Wittinghofer A. 1998; GTPase-activating proteins: helping hands to complement an active site. Trends Biochem Sci 23:257–262 [CrossRef]
    [Google Scholar]
  65. Sekiya K., Ohishi M., Ogino T., Tamano K., Sasakawa C., Abe A. 2001; Supermolecular structure of the enteropathogenic Escherichia coli type III secretion system and its direct interaction with the EspA-sheath-like structure. Proc Natl Acad Sci USA 98:11638–11643 [CrossRef]
    [Google Scholar]
  66. Shaw R. K., Daniell S., Ebel F., Frankel G., Knutton S. 2001; EspA filament-mediated protein translocation into red blood cells. Cell Microbiol 3:213–222 [CrossRef]
    [Google Scholar]
  67. Stender S., Friebel A., Linder S., Rohde M., Mirold S., Hardt W. D. 2000; Identification of SopE2 from Salmonella typhimurium , a conserved guanine nucleotide exchange factor for Cdc42 of the host cell. Mol Microbiol 36:1206–1221
    [Google Scholar]
  68. Taylor K. A., O’Connell C. B., Luther P. W., Donnenberg M. S. 1998; The EspB protein of enteropathogenic Escherichia coli is targeted to the cytoplasm of infected HeLa cells. Infect Immun 66:5501–5507
    [Google Scholar]
  69. Taylor K. A., Luther P. W., Donnenberg M. S. 1999; Expression of the EspB protein of enteropathogenic Escherichia coli within HeLa cells affects stress fibers and cellular morphology. Infect Immun 67:120–125
    [Google Scholar]
  70. Tran Van Nhieu G., Caron E., Hall A., Sansonetti P. J. 1999; IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells. EMBO J 18:3249–3262 [CrossRef]
    [Google Scholar]
  71. Vallance B. A., Finlay B. B. 2000; Exploitation of host cells by enteropathogenic Escherichia coli . Proc Natl Acad Sci USA 97:8799–8806 [CrossRef]
    [Google Scholar]
  72. Wachter C., Beinke C., Mattes M., Schmidt M. A. 1999; Insertion of EspD into epithelial target cell membranes by infecting enteropathogenic Escherichia coli . Mol Microbiol 31:1695–1707 [CrossRef]
    [Google Scholar]
  73. Warawa J., Kenny B. 2001; Phosphoserine modification of the enteropathogenic E. coli Tir molecule is required to trigger conformational changes and efficient pedestal elongation. Mol Microbiol 42:1269–1280
    [Google Scholar]
  74. Warawa J., Finlay B. B., Kenny B. 1999; Type III secretion-dependent hemolytic activity of enteropathogenic Escherichia coli . Infect Immun 67:5538–5540
    [Google Scholar]
  75. Wilson R. K., Shaw R. K., Daniell S., Knutton S., Frankel G. 2001; Role of EscF, a putative needle complex protein, in the type III protein translocation system of enteropathogenic Escherichia coli . Cell Microbiol 3:753–762 [CrossRef]
    [Google Scholar]
  76. Wolff C., Nisan I., Hanski E., Frankel G., Rosenshine I. 1998; Protein translocation into host epithelial cells by infecting enteropathogenic Escherichia coli . Mol Microbiol 28:143–155
    [Google Scholar]
  77. Zhu C., Agin T. S., Elliott S. J., Johnson L. A., Thate T. E., Kaper J. B., Boedeker E. C. 2001; Complete nucleotide sequence and analysis of the locus of enterocyte effacement from rabbit diarrheagenic Escherichia coli RDEC-1. Infect Immun 69:2107–2115 [CrossRef]
    [Google Scholar]
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