1887

Abstract

Mutations in a gene, (rhizobial iron regulator), caused high-level, constitutive expression of at least eight operons whose transcription is normally Fe-responsive and whose products are involved in the synthesis or uptake of siderophores, or in the uptake of haem or of other iron sources. Close homologues of RirA exist in other rhizobia and in the pathogen ; many other bacteria have deduced proteins with more limited sequence similarity. None of these homologues had been implicated in Fe-mediated gene regulation. Transcription of itself is about twofold higher in cells grown in Fe-replete than in Fe-deficient growth media. Mutations in reduced growth rates in Fe-replete and -depleted medium, but did not appear to affect symbiotic N fixation.

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2002-12-01
2019-10-15
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