1887

Abstract

The ascomycete is an emerging human pathogen frequently found in soil and polluted water. A peptidopolysaccharide antigen has been isolated from mycelial forms of , and characterized using chemical and immunological methods. Monosaccharide composition, methylation analysis, and H- and C-NMR spectra indicated the presence of a rhamnomannan with a structure distinct from those of similar components isolated from other fungi, containing Rha(1→3)Rha epitopes on side chains which may be linked (1→3) to (1→6)-linked mannose. The peptidorhamnomannan from reacted poorly with an antiserum raised against whole cells of and strongly with one against hyphae. These characteristics and immunological differences suggest that this major rhamnose-containing antigen of may be useful for the specific diagnosis of infections attributable to this fungus.

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2001-06-01
2019-10-21
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