@article{mbs:/content/journal/micro/10.1099/00221287-147-3-599, author = "Jensen, Slade O. and Reeves, Peter R.", title = "Molecular evolution of the GDP-mannose pathway genes (manB and manC) in Salmonella entericaThe GenBank accession numbers for the sequences reported in this paper are AY012160–AY012201.", journal= "Microbiology", year = "2001", volume = "147", number = "3", pages = "599-610", doi = "https://doi.org/10.1099/00221287-147-3-599", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-147-3-599", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", keywords = "Salmonella enterica", keywords = "CA, colanic acid", keywords = "GDP-d-mannose pathway", keywords = "concerted evolution", keywords = "gene conversion", keywords = "lateral transfer", abstract = "The evolutionary history of the GDP-mannose pathway in Salmonella enterica was studied via sequencing manB and manC genes from 13 representative strains for O antigens containing mannose and/or sugar derivatives of GDP-D-mannose. In addition, colanic acid (CA) manB and manC genes were sequenced from selected strains, as the basis for a detailed comparison. Interestingly, including the eight previously characterized O antigen gene clusters, 12 of the 21 S. enterica strains studied in total (each representing a different O antigen structure) possess a manB gene which displays DNA identity, ranging from 93 to 99%, to the CA manB gene of S. enterica LT2. Furthermore, the CA-like manB genes (as well as the CA manB and manC genes) display subspecies specificity, and the CA and CA-like manB genes (for individual strains) appear to be evolving in concert via gene conversion events. In comparison, the manC genes were generally not CA-like, a situation also apparent in Escherichia coli,and therefore most strongly reflected the evolutionary history of the S. enterica Oantigen GDP-mannose pathway. It appears that, in relatively recent times, gene capture from a distant source has occurred infrequently, and that groups of manB and manC genes have been maintained and are continuing to evolve within S. enterica and more closely related species.", }