1887

Abstract

The yeast gene encodes glucosamine-6-phosphate acetyltransferase which catalyses the reaction of glucosamine 6-phosphate with acetyl-CoA to form -acetylglucosamine 6-phosphate, a fundamental precursor in UDP--acetylglucosamine biosynthesis. mutants lacking were viable in the presence of -acetylglucosamine. To confirm the physiological importance of , the virulence of a Δ null mutant was examined in a mouse model of candidiasis. When injected intravenously into mice, the virulence of the Δ null mutant was significantly attenuated. The reduced virulence appeared to be the result of rapid clearance from host tissue. These data suggest that is required for survival of the fungus in host animals, probably because an insufficient level of -acetylglucosamine is available from the host tissues.

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2000-07-01
2019-12-08
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