1887

Abstract

The interaction between serotypes and macrophages is potentially instrumental in determining the outcome of infection. The nature of this interaction was characterized with respect to virulence and serotype-host specificity using pigs as the infection model. Experimental infection with , or resulted in enteric, systemic or asymptomatic infection, respectively, which correlates well with the association of with systemic disease in pigs in epidemiological studies. Persistence within porcine alveolar macrophages did not directly correlate with virulence since persisted in the highest numbers, and in the lowest. Comparison to other studies revealed that the relatively high persistence of in macrophages correlates with its virulence in a broad range of animals: this could be a virulence mechanism for broad-host-range serotypes. There were little or no significant differences in the induction of pro-inflammatory cytokines by macrophages infected with the three serotypes. and , but not , damaged porcine macrophages, and the mechanism of damage did not resemble apoptosis. In conclusion, the virulence of serotypes in pigs did not directly correlate with their interaction with porcine macrophages . The interaction of and macrophages may not accurately model their interaction , and this will form the basis of further study.

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2000-07-01
2019-12-05
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