1887

Abstract

Transfer of VanB-type resistance to glycopeptides among enterococci has been reported to be associated with the movement of large chromosomal genetic elements or of plasmids. The authors report the characterization of the 34 kb transposon Tn borne by a plasmid related to pAD1 and conferring vancomycin resistance in clinical isolates of spp. Tn contained 30 ORFs and appeared to be organized like the Tn family of conjugative transposons into three functional regions: (i) the right end, implicated in the excision–integration process; (ii) the central part, in which the operon replaces the (M) gene; and (iii) the left extremity, in which eight of the 18 ORFs could be implicated in the conjugative transfer.

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2000-06-01
2019-11-13
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