1887

Abstract

A unique chlorinated macrocyclic lactone, termed oocydin A, was isolated from a strain of growing as an epiphyte on , an aquatic plant native to the Carrao river of the Venezuelan-Guyanan region of South America. The lactone has a molecular mass of 470 Da, and contains one atom of chlorine, a carboxyl group and a tetrahydrofuran ring internal to a larger macrocyclic ring. MICs of approximately 003 μg ml were noted for oocydin A against such phytopathogenic oomycetes as , and . With regard to the true fungi, oocydin A had either minimal or no effect against certain Fungi Imperfecti (including several pathogens of humans), two ascomycetes and a basidiomycete. Oocydin A may have potential as an antimycotic in agricultural applications and especially for crop protection.

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1999-12-01
2020-11-28
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