1887

Abstract

Summary: Protein secretion in Gram-negative bacteria is often dependent on the general secretory pathway (GSP). In , this system requires at least 12 Xcp (Gsp) proteins, which are proposed to constitute a multiprotein complex localized in the bacterial envelope. Hitherto, little was known about the mutual interactions between Xcp proteins. In this study, mutants affected in the gene encoding a bitopic inner-membrane protein were analysed to investigate the role of this protein in the architecture of the secretory machinery. The absence of XcpZ resulted in a decreased amount of XcpY. Reciprocally, XcpZ was not detectable in a mutant demonstrating a mutual stabilization of these two proteins. These results strongly suggest that XcpZ and XcpY interact within the functional secretory apparatus.

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/content/journal/micro/10.1099/00221287-144-12-3379
1998-12-01
2019-11-12
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-144-12-3379
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