@article{mbs:/content/journal/micro/10.1099/00221287-143-7-2295, author = "Cavard, Danièle", title = "Role of the colicin A lysis protein in the expression of the colicin A operon", journal= "Microbiology", year = "1997", volume = "143", number = "7", pages = "2295-2303", doi = "https://doi.org/10.1099/00221287-143-7-2295", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-143-7-2295", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", keywords = "globomycin", keywords = "Escherichia coli", keywords = "colicin lysis protein", keywords = "colicin", keywords = "heat-shock protein", abstract = "Summary: The involvement of the cal gene, which encodes the colicin A lysis protein, in the expression of the colicin A operon is demonstrated. Colicin A synthesis by Escherichia coli was studied at various temperatures in cells containing either the wild-type colicin A operon or the colicin A operon with the cal gene deleted. The amount of colicin A produced was lower in cells containing the colicin A operon devoid of the cal gene than in wild-type cells. In cells treated with the antibiotic globomycin, the synthesis of colicin A was blocked in null cal mutants at all temperatures. It was blocked only at low temperature in cells containing the wild-type colicin A operon, but not in cells subjected to heat shock or azide treatment. The cal gene product may be an activator of colicin A expression and of its own expression. An unidentified product, possibly a heat-shock protein, may also be involved and could complement the cal gene product in some situations.", }