Summary: The tetracycline resistance determinant (S) was first detected in antibiotic multiresistant BM4210 and subsequently in strains of Transfer of (S) from clinical isolate BM4242 to strains JH2-2 and OG1RF was found to require the presence in the donor strain of the 55 kb conjugative plasmid pIP825. Comparison of restriction endonuclease generated maps of the donor, the two recipients, and of four transconjugants indicated that transfer of (S) (i) was from chromosome to chromosome, (ii) resulted in the acquisition of an approximately 40 kb element in the same chromosomal region and (iii) was associated with the exchange of large chromosomal fragments. Similar observations were made following conjugal transfer of (S) from four other clinical isolates.


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