@article{mbs:/content/journal/micro/10.1099/00221287-143-3-971, author = "Lysenko, Elena and Ogura, Teru and Cutting, Simon M.", title = "Characterization of the ftsH gene of Bacillus subtilis", journal= "Microbiology", year = "1997", volume = "143", number = "3", pages = "971-978", doi = "https://doi.org/10.1099/00221287-143-3-971", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-143-3-971", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", keywords = "protease", keywords = "FtsH", keywords = "B. subtilis", keywords = "AAA-protein family", keywords = "cell cycle", abstract = "Members of the AAA-protein family are found in both prokaryotes and eukaryotes. These ATPases are involved in a number of diverse activities ranging from protein secretion to cell cycle control. This paper reports the functional analysis of the Bacillus subtilis ftsH gene, which encodes a member of this protein family. In cells containing reduced levels of a truncated FtsH protein cell growth was impaired under certain nutritional conditions. In a hypersaline environment FtsH was required in increased amounts for the cells' recovery from osmotic stress. In the absence of FtsH the abundance of several of the major penicillin-binding proteins (PBP2A and 2B) in the cytoplasmic membrane was affected. Lastly, it has been established that FtsH is required for entry into the developmental life cycle.", }