@article{mbs:/content/journal/micro/10.1099/00221287-143-12-3757, author = "Northrop, Frederick D. and Ljubojevic, Srdjan and Davies, Julia M.", title = "Influence of Na+ and anions on the dimorphic transition of Candida albicans", journal= "Microbiology", year = "1997", volume = "143", number = "12", pages = "3757-3765", doi = "https://doi.org/10.1099/00221287-143-12-3757", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-143-12-3757", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", keywords = "pH regulation", keywords = "Candida albicans", keywords = "anions", keywords = "lithium", keywords = "Na+", abstract = "The effect of Na+ (CI- or gluconate salt) on growth and dimorphic potential of the pathogenic yeast Candida albicans has been examined. Profiles of germ tube formation as a function of salt addition, pH and temperature indicated Na+ inhibition of germ tube outgrowth at high ambient pH (pH 8.0) which was exacerbated by replacement of CI- with gluconate (as an impermeant analogue). At acidic pH (pH 5.5) and permissive temperature (37 °), gluconate alone promoted the dimorphic transition. Rates of glucose-induced medium acidification and plasma membrane H+-ATPase activity have been measured to assess whether salt treatments could retard the cytoplasmic alkalinization known to precede germ tube formation. The precise site of Na+ action remains unclear but the anion effects may be interpreted in terms of anion-exchanger and channel activity acting to modulate cytosolic pH.", }