A search for mutants defective in filamentous growth led to the isolation of a mutant strain with an insertion mutation in the gene. encodes the phosphatidylinositol/phosphatidylcholine transfer protein, an essential protein in the yeast In the dimorphic yeast is needed for growth only in the hyphal form and is not required for growth in the yeast form. However, unlike is probably essential for growth. Northern blot analysis and PCR amplification of transcripts produced from the gene demonstrated that two transcripts differing at their 3′ ends were produced. The two transcripts may regulate the activity of so that Sec14p can perform two functions in One function may be an essential function analogous to the function of Sec14p in and the second function may be important during filamentous growth, analogous to the function of Sec14p in


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