Some mutants of defective in exopolysaccharide synthesis, were phenotypically complemented by two different regions of cloned chromosomal DNA. One of these had been shown to contain a gene termed a novel class of transcriptional regulator. The other contains a gene termed which encodes a glycosyltransferase that is involved in one of the early steps in exopolysaccharide synthesis. Mutations in reduced the expression of and a model to account for the complementation of certain alleles by both and is presented. Tn insertions into which expressed alkaline phosphatase activity were isolated and mapped, confirming the membrane location of the gene product. Some of these mutations were dominant, causing merodiploids to be non-mucoid. is linked to two genes, one encoding an Ω-aminotransferase and the other encoding an aldehyde dehydrogenase.


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