The usage of alternative synonymous codons in (and genes has been investigated. This species is a member of the high-G + C Gram-positive bacteria, with a genomic G + C content around 65 mol%. This G + C-richness is reflected in a strong bias towards C- and Gending codons for every amino acid: overall, the G + C content at the third positions of codons is 83%. However, there is significant variation in codon usage patterns among genes, which appears to be associated with gene expression level. From the variation among genes, putative optimal codons were identified for 15 amino acids. The degree of bias towards optimal codons in an gene is correlated with that in homologues from and The set of selectively favoured codons seems to be quite highly conserved between and another high-G + C Gram-positive bacterium, Corynebacterium even though the genome and overall codon usage of the latter are much less G + C-rich.


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