We compared multiple isolates of the two varieties of , as well as previously characterized representative isolates, for their electrophoretic karyotypes using pulsed-field electrophoresis. The two varieties could be clearly distinguished based upon the size of the smallest chromosome. The smallest chromosome for isolates of the gattii variety (serotypes B and C) was found to be 400–700 kb in size. The smallest chromosome for isolates of the neoformans variety was consistently found to be larger, approximately 770 kb in size. Isolates of the variety averaged 13 chromosomes while the variety averaged 12. The size of the genome was found to be approximately 23 megabases. Isolates of var. tended to be more conserved than those of var. with regard to gene position.


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