Plasmids conferring mupirocin resistance were prepared from isolates of obtained from four patients in the same ward. The plasmids are related and in all of them the gene conferring mupirocin resistance (A) is flanked by copies of IS in direct repeat. In two plasmids A and IS have been duplicated and in one of these plasmids (pJ3358) a small pT181-like plasmid conferring tetracycline resistance is present flanked by copies of IS Filter mating with a strain containing pJ3358 as donor and selection on tetracycline sometimes resulted in transfer of the pT181-like plasmid containing a copy of IS Analysis showed that the pT181-like plasmid with the insertion of IS is present in high copy number and that the IS element is inserted in the copy number control region of the plasmid.


Article metrics loading...

Loading full text...

Full text loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error