1887

Abstract

Plasmids conferring mupirocin resistance were prepared from isolates of obtained from four patients in the same ward. The plasmids are related and in all of them the gene conferring mupirocin resistance (A) is flanked by copies of ISin direct repeat. In two plasmids A and IShave been duplicated and in one of these plasmids (pJ3358) a small pT181-like plasmid conferring tetracycline resistance is present flanked by copies of ISFilter mating with a strain containing pJ3358 as donor and selection on tetracycline sometimes resulted in transfer of the pT181-like plasmid containing a copy of ISAnalysis showed that the pT181-like plasmid with the insertion of ISis present in high copy number and that the ISelement is inserted in the copy number control region of the plasmid.

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1994-10-01
2021-07-25
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