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SUMMARY: The sensitivity to various antibiotics of certain facultatively anaerobic bacteria when growing under aerobic or anaerobic conditions was compared. The antibiotics tested were: dihydrostreptomycin, penicillin, chloramphenicol, erythromycin, carbomycin, chlortetracycline, oxytetracycline, tetracycline. Dihydrostreptomycin was unique amongst the antibiotics tested in being less active against facultative anaerobes when they were growing anaerobically than when growing aerobically. Dihydrostreptomyein was relatively inactive against Clostridium welchii and C. novyi, and its action was governed by the inoculum size. Dihydrostreptomyein is not a useful selective agent for the isolation of C. welchii.
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