1887

Abstract

Summary: A hyaluronidase preparation was isolated by the methods of protein precipitation from the culture fluid of a capsulated group C streptococcus cultivated in a serum-free medium. The preparation was active in the mucin clot prevention and turbidimetric tests for hyaluronidase and rapidly destroyed the capsules of group A and group C streptococci. The enzyme resembled other streptococcal hyaluronidases in its reaction to pH changes but differed from these both in its thermolability and antigenic specificity.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-14-1-143
1956-02-01
2022-01-27
Loading full text...

Full text loading...

/deliver/fulltext/micro/14/1/mic-14-1-143.html?itemId=/content/journal/micro/10.1099/00221287-14-1-143&mimeType=html&fmt=ahah

References

  1. Beiler J.M., Martin G.J. 1948; Inhibition of hyaluronidase action by derivatives of hesperidin. J. biol. Chem. 174:31
    [Google Scholar]
  2. Elliott S.D. 1945; A proteolytic enzyme produced by group A streptococci with special reference to its effect on the type-specific M antigen. J. exp. Med. 81:573
    [Google Scholar]
  3. Faber V. 1953; Anti-streptococcal hyaluronidase. I. The turbidimetric method for determination of anti-streptococcal-hyaluronidase (ASH) in serum. Acta path, microbiol. scand. 32:147
    [Google Scholar]
  4. Faber V., Rosendal K. 1954; Streptococcal hyaluronidase. II. Studies on the production of hyaluronic acid and hyaluronidase by representatives of all types of hemolytic streptococci belonging to group A. Acta path, microbiol. scand. 35:159
    [Google Scholar]
  5. Hahn L. 1952; Inhibitors of hyaluronidase. Nature; Lond.: 170282
    [Google Scholar]
  6. Hale C.W. 1944; Studies on diffusing factors. 5. The influence of some environmental conditions on the activity of hyaluronidase. Biochem. J. 38:368
    [Google Scholar]
  7. Harris T.N., Harris S. 1950; A comparison of physicochemical measurements of hyaluronidase and of neutralizing antibodies thereto. J. Immunol. 65:255
    [Google Scholar]
  8. Hobby G.L., Dawson M.H., Meyer K., Chaffee E. 1941; The relationship between spreading factor and hyaluronidase. J. exp. Med. 73:109
    [Google Scholar]
  9. Humphrey J.H., Jaques R. 1953; Hyaluronidase: correlation between biological assay and other methods of assay. Biochem. J. 53:59
    [Google Scholar]
  10. McClean D. 1942; The in-vivo decapsulation of streptococci by hyaluronidase. J. Path. Bact. 54:284
    [Google Scholar]
  11. McClean D. 1943; Studies on diffusing factors. 2. Methods of assay of hyaluronidase and their correlation with skin diffusing activity. Biochem. J. 37:169
    [Google Scholar]
  12. MaClennan A.P. 1956; The production of capsules, hyaluronic acid and hyaluronidase by group A and group C streptococci. J. gen. Microbiol. 14:134
    [Google Scholar]
  13. Meyer K., Rapport M.M. 1952; Hyaluronidases. Advanc. Enzymol. 13:199
    [Google Scholar]
  14. Mycek M.J., Elliott S.D., Fruton J.S. 1952; The specificity of a crystalline streptococcal proteinase. J. biol. Chem. 197:637
    [Google Scholar]
  15. Pike R.M. 1948a; Streptococcal hyaluronic acid and hyaluronidase. 1. Hyaluronidase activity of non-capsulated group A streptococci. J. infect. Dis. 83:1
    [Google Scholar]
  16. Pike R.M. 1948b; Streptococcal hyaluronic acid and hyaluronidase. II. Production and subsequent destruction of hyaluronic acid by certain strains of group A streptococci. J. infect. Dis. 83:12
    [Google Scholar]
  17. Quinn R.W., Seastone C.V., Weber R.W. 1953; The relationship of the antigenic characteristics of streptococci and specific antibody responses following streptococcal infections. J. infect. Dis. 93:57
    [Google Scholar]
  18. Rodney G., Swanson A.L., Wheeler L.M., Smith G.N., Worrel C.S. 1950; The effect of a series of flavonoids on hyaluronidase and some other related enzymes. J. biol. Chem. 183:739
    [Google Scholar]
  19. Rogers H.J. 1944; A simplified culture medium for the production and purification of hyaluronidase. J. Path. Bact. 56:284
    [Google Scholar]
  20. Rogers H.J. 1946; The influence of hydrolyzates of hyaluronate upon hyaluronidase production by micro-organisms. Biochem. J. 40:583
    [Google Scholar]
  21. Rogers H.J. 1948; The complexity of the hyaluronidases produced by micro-organisms. Biochem. J. 42:633
    [Google Scholar]
  22. Weiner L.M., Seastone C.V. 1951; Chemical inhibition of decapsulation in the beta hemolytic streptococcus. Proc. Soc. exp. Biol., N.Y. 78:466
    [Google Scholar]
  23. Wenner H.A., Gibson D.M., Jaques R. 1951; Specificities of hyaluronidases formed by several groups of streptococci. Proc. Soc. exp. Biol., N.Y. 76:585
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-14-1-143
Loading
/content/journal/micro/10.1099/00221287-14-1-143
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error