RT Journal Article SR Electronic(1) A1 Griffith, Julia M. A1 Coffey, Michael D. A1 Grant, Bruce R.YR 1993 T1 Phosphonate inhibition as a function of phosphate concentration in isolates of Phytophthora palmivora JF Microbiology, VO 139 IS 9 SP 2109 OP 2116 DO https://doi.org/10.1099/00221287-139-9-2109 PB Microbiology Society, SN 1465-2080, AB SUMMARY: Three isolates of Phytophthora palmivora showing differing sensitivities to phosphonate were grown in the presence of a uniform concentration of the anion (1 mM), together with concentrations of phosphate which varied from zero to 3 mM. The phosphonate-sensitive isolate was inhibited by phosphonate at all levels of phosphate, but the resistant isolates were inhibited by phosphonate only when phosphate was limiting to growth and were able to exclude phosphonate more effectively than the sensitive isolate at higher concentrations of phosphate. The percentage inhibition in each strain was proportional to the internal concentration of phosphonate, but the slope of the plot of inhibition against internal phosphonate varied between strains. Differences in the capacity to discriminate between phosphate and phosphonate therefore provide part of, but not the whole explanation for differences in sensitivity between isolates. There was a significant increase in the internal concentration of orthophosphate in the mycelia which were inhibited by phosphonate., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-139-9-2109