%0 Journal Article %A Tower, Paula A. %A Alexander, David B. %A Johnson, Linda L. %A Riscoe, Michael K. %T Regulation of methylthioribose kinase by methionine in Klebsiella pneumoniae %D 1993 %J Microbiology, %V 139 %N 5 %P 1027-1031 %@ 1465-2080 %R https://doi.org/10.1099/00221287-139-5-1027 %I Microbiology Society, %X 5-Methylthioribose (MTR) kinase catalyses a key step in the recycling of methionine from 5′-methylthioadenosine, a co-product of polyamine biosynthesis, in Klebsiella pneumoniae. In defined medium lacking methionine, K. pneumoniae exhibits abundant MTR kinase activity. When the bacterium is transferred to a medium containing 10 mm-methionine, the specific activity of MTR kinase decreases in a fashion consistent with repression of new enzyme synthesis and dilution of existing enzyme by cell division. The specific activity of methionine synthase decreases to a similar degree under the same conditions. In Escherichia coli and Salmonella typhimurium, the gene for methionine synthase is co-ordinately controlled as part of the methionine regulon. Taken together, our results indicate that a methionine regulon may function in K. pneumoniae and that expression of MTR kinase may be under its control. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-139-5-1027