1887

Abstract

The inducible macrolide-lincosamide-streptogramin B resistance determinant, , from 590 was cloned in CSH26. The DNA sequence of was similar to that of or from , suggesting that -like genes have been distributed in strains by transposition. Expression of was achieved in a minicell system, and the rRNA methyltransferase product of was purified. The molecular mass of the enzyme was 58 kDa, and it was concluded to be a homodimer. Its biochemical characteristics were different from those of methyltransferase.

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1993-03-01
2021-05-13
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