Staurosporine is a strong inhibitor of protein kinases. At low concentrations, this antibiotic inhibited the growth of both protoplasts and mycelium of . Its minimum inhibitory concentrations were 6.5 μM and 9.6 μM for protoplasts and mycelium, respectively. At a lower concentration (0.54 μM), it caused swelling of hyphal tips and subapical regions while some hyphae became stubby and bulbous. The phenomena were compared with the morphological effects of polyoxin D, which is a competitive inhibitor of chitin synthase. The results suggest the involvement of protein kinases(s) in regulation of apical growth of fungi.


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