The activation of catalase genes in response to oxidative stress may contribute to the intracellular survival of mycobacteria. In this report, the nucleotide sequence of a mycobacterial catalase gene is described. The deduced protein sequence of this gene (M185) was 60% identical to the hydroperoxidase I (HPI) protein, 59% identical to the (HPI) catalase, and 47% identical to a peroxidase. The M185 protein, expressed in , has also been shown to have peroxidase and catalase activities. Furthermore, Southern blot hybridizations, which demonstrated that a M185 gene probe hybridizes with chromosomal DNA from thirteen different strains of mycobacteria, suggest that this catalase-peroxidase gene is prevalent in the mycobacterial genus. The availability of catalase gene probes should permit an evaluation, at the molecular level, of the role of catalase in mycobacterial pathogenesis.


Article metrics loading...

Loading full text...

Full text loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error