1887

Abstract

Summary: In order to provide a profile of the plasmid gene pool in prior to the clinical use of antibiotics, a molecular genetic analysis was made of plasmids in strains collected by E. D. G. Murray between 1917 and 1954. These pre-antibiotic era (PAE) salmonellae contain conjugative plasmids of the same incompatibility groups as contemporary enterobacterial plasmids. Upon analysis of total plasmid content, 42 plasmids, sized between 23 and 72 MDa, were found. We defined and investigated six groups of these PAE plasmids in terms of three groups of genes; those involved in plasmid maintenance and incompatibility, DNA repair and virulence. Of the five groups, three were replicon-typed to groups IncI1, IncX and IncFII; one group exhibited no homology to contemporary Inc/Rep probes, and one group represented virulence plasmids containing a common plasmid-partitioning locus. The results indicated that most of the PAE groups were progenitors of contemporary R-plasmids, except for the virulence plasmids, which have generally not evolved as vectors of antibiotic resistance.

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1992-01-01
2021-10-26
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References

  1. Brown A. M. C., Willetts N. S. 1981; A physical and genetic map of the IncN plasmid R46. Plasmid 5:188–201
    [Google Scholar]
  2. Brown D. J., Munro D. S., Platt D. J. 1986; Recognition of the cryptic plasmid pSLT, by restriction fingerprinting and a study of its incidence in Scottish salmonella isolates. Journal of Hygiene 97:193–197
    [Google Scholar]
  3. Callow B. R. 1959; A new phage-typing scheme for Salmonella typhimurium . Journal of Hygiene 57:346–359
    [Google Scholar]
  4. Chambers R. M., Mcadam P., De sa J. D. H., Ward L. R., Rowe B. 1987; A phage-typing scheme for Salmonella virchow . FEMS Microbiology Letters 40:155–157
    [Google Scholar]
  5. Couturier M., Bex F., Berquist P. L., Maas W. K. 1988; Identification and classification of bacterial plasmids. Microbiological Reviews 52:375–395
    [Google Scholar]
  6. Craigie J., Felix A. 1947; Typing of typhoid bacilli with Vi bacteriophage. Lancet i:823–827
    [Google Scholar]
  7. Datta N. 1979 Plasmid classification ; incompatibility grouping. In Plasmids of Medical, Environmental and Commercial Importance pp 3–12 Edited by Timmis K. N., Puhler A. Amsterdam;: Elsevier/North Holland Press;
    [Google Scholar]
  8. Datta N., Hughes V. M. 1983 Plasmids of the same Inc groups in enterobacteria before and after the medical use of antibiotics. Nature London : 306616–617
    [Google Scholar]
  9. Fee B. E., Dempsey W. B. 1986; Cloning, mapping, and sequencing of plasmid R100 traM finPgenes. Journal of Bacteriology 167:336–345
    [Google Scholar]
  10. Glazebrook J. A., Grewal K. K., Strike P. 1986; Molecular analysis of the UV protection and mutation genes carried by the I incompatibility group plasmid TP110. Journal of Bacteriology 168:251–256
    [Google Scholar]
  11. Grinsted J., De la cruz F., Schmitt R. 1990; The Tn27 subgroup of bacterial transposable elements. Plasmid 24:163–189
    [Google Scholar]
  12. Herrera G., Urios A., Aleixandre V., Blanco M. 1988; UV light-induced mutability in Salmonella strains containing the umuDC or the mucABoperon: evidence for a umuC function. Mutation Research 198:9–13
    [Google Scholar]
  13. Hughes V. M., Datta N. 1983; Conjugative plasmids in bacteria of the ‘pre-antibiotic’ era. Nature, London 302:725–726
    [Google Scholar]
  14. Jones G. W., Rabert D. K., Svinarich D. M., Whitfield H. J. 1982; Association of adhesive, invasive and virulent phenotypes of Salmonella typhimurium with autonomous 60-megadalton plasmids. Infection and Immunity 38:476–486
    [Google Scholar]
  15. Kado C. I., Liu S.-T. 1981; Rapid procedure for detection of large and small plasmids. Journal of Bacteriology 145:1365–1375
    [Google Scholar]
  16. Kauffmann F. 1972 Serological Diagnosis of Salmonella Species Copenhagen; Munksgaard:
    [Google Scholar]
  17. Maniatis T., Fritsch E. F., Sambrook J. 1982 Molecular Cloning. A Laboratory Manual Cold Spring Harbor, NY: Cold Spring Harbor Laboratory;
    [Google Scholar]
  18. Matsui H., Kawahara K., Terakado N., Danbara H. 1990a; Nucleotide sequence of a gene encoding a 29kDa polypeptide in mba region of the virulence plasmid, pKDS50, of Salmonella choleraesuis . Nucleic Acids Research 18:1055
    [Google Scholar]
  19. Matsui H., Kawahara K., Terakado N., Danbara H. 1990a; Nucleotide sequences of genes encoding 32kDa and 70kDa polypeptides in mba region of the virulence plasmid, pKDS50, of Salmonella choleraesuis . Nucleic Acids Research 18:1055
    [Google Scholar]
  20. Norel F., Coynault C., Miras I., Hermant D., Popoff M. Y. 1989a; Cloning and expression of plasmid DNA sequences involved in Salmonellaserotype typhimurium virulence. Molecular Microbiology 3:733–743
    [Google Scholar]
  21. Norel F., Coynault C., Miras I., Hermant D., Popoff M. Y. 19896; Nucleotide sequence of the plasmid-borne virulence gene mkfA encoding a 28kd polypeptide from Salmonella typhimurium . Research in Microbiology 140:263–265
    [Google Scholar]
  22. Norel F., Coynault C., Miras I., Hermant D., Popoff M. Y. 1989c; Nucleotide sequence of the plasmid-bome virulence gene mkfB encoding a 28kd polypeptide from Salmonella typhimurium . Research in Microbiology 140:455–457
    [Google Scholar]
  23. Ou J. T., Baron L. S., Dai X., Life C. A. 1990; The virulence plasmids of Salmonellaserovars typhimurium, choleraesuis, dublin enteritidis,and the cryptic plasmids of Salmonellaserovars Copenhagen sendaibelong to the same incompatibility group, but not those of Salmonellaserovars durban, gallinarum, give, infantisand pullorum . Microbial Pathogenesis 8:101–107
    [Google Scholar]
  24. Pohl P., Lintermans F., Bex F., Desmyter A., Dreze P., Fonteyne P. A., Couturier M. 1987; Propriétés phénotypiques et génotypiques de quartre plasmides de virulence de Salmonella typhimurium . Annals de l’institut Pasteur/Microbiologie 138:523–528
    [Google Scholar]
  25. Pullinger G. D., Baird G. D., Williamson C. M., Lax A. J. 1989; Nucleotide sequence of a plasmid gene involved in the virulence of salmonellas. Nucleic Acids Research 17:7983
    [Google Scholar]
  26. Rhen M., Virtanen M., Makela P. H. 1989; Localization by insertional mutagenesis of a virulence-associated region in the Salmonella typhimurium96 kilobase pair virulence plasmid. Microbial Pathogenesis 6:153–158
    [Google Scholar]
  27. Sedgewick S. G., Thomas S. M., Hughes V. M., Lodwick D., Strike P. 1989; Mutagenic DNA repair genes on plasmids from the ‘pre-antibiotic era’. Molecular and General Genetics 218:323–329
    [Google Scholar]
  28. Stalker D. M., Helinski D. R. 1985; DNA Segments of the IncX plasmid R485 determining replication and incompatibility with R6K. Plasmid 14:245–254
    [Google Scholar]
  29. Strike P., Lodwick D. 1987; Plasmid genes affecting DNA repair and mutation. Journal of Cell ScienceSuppl 6:303–321
    [Google Scholar]
  30. Tinge S. A., Curtiss R. 1990a; III, Isolation of the replication and partitioning regions of the Salmonella typhimurium virulence plasmid and stabilization of heterologous replicons. Journal of Bacteriology 172:5266–5277
    [Google Scholar]
  31. Tinge S. A., Curtiss R. 1990b; III, Conservation of Salmonella typhimuriumvirulence plasmid maintenance regions among Salmonella serovars as a basis for plasmid curing. Infection and Immunity 58:3084–3092
    [Google Scholar]
  32. Ward L. R., De sa J. D. H., Rowe B. 1987; A phage-typing scheme for Salmonella enteritidis . Epidemiology and Infection 99:291–294
    [Google Scholar]
  33. Woodward M. J., Mclaren I., Wray C. 1989; Distribution of virulence plasmids within salmonellae. Journal of General Microbiology 135:503–511
    [Google Scholar]
  34. Watanabe T., Nishida H., Ogata C., Arai T., Sato S. 1964; Episome-mediated transfer of drug resistance in Enterobacteriaceae . Journal of Bacteriology 88:716–726
    [Google Scholar]
  35. Williamson C. M., Baird G. D., Manning E. J. 1988; A common virulence region on plasmids from eleven serotypes of Salmonella . Journal of General Microbiology 134:975–982
    [Google Scholar]
  36. Willetts N., Skurray R. 1980; The conjugation system of F-like plasmids. Annual Review of Genetics 14:41–76
    [Google Scholar]
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