RT Journal Article SR Electronic(1) A1 Robson, Geoffrey D. A1 Wiebe, Marilyn G. A1 Trinci, Anthony P. J.YR 1991 T1 Exogenous cAMP and cGMP modulate branching in Fusarium graminearum JF Microbiology, VO 137 IS 4 SP 963 OP 969 DO https://doi.org/10.1099/00221287-137-4-963 PB Microbiology Society, SN 1465-2080, AB Summary: A study was made of the effects of adenosine 3',5'-cyclic monophosphate (cAMP), guanosine 3',5'-cyclic monophosphate (cGMP) and choline on the morphology and growth of a wild-type strain (A 3/5) and a highly branched, “colonial” mutant strain (C106) of Fusarium graminearum. Addition of up to 50 mm-cAMP or cGMP to the medium had no effect on the specific growth rate of strain A 3/5. For strain A 3/5, but not for strain C106, exogenous cAMP caused significant decreases in both mean hyphal extension rate (E) and hyphal growth unit length (G), i.e. cAMP caused mycelia of strain A 3/5 to branch profusely. By contrast, for both strains, cGMP caused significant increases in both E and G, i.e. exogenous cGMP caused mycelia to branch more sparsely. The effects of exogenous cGMP and choline in increasing E and G were synergistic, but the effects of cGMP and choline counteracted the effect of cAMP. The mutant phenotype of strain C106 was not correlated with altered levels of endogenous cAMP or cGMP., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-137-4-963