1887

Abstract

A family of peptide antimycotics, termed pseudomycins, has been isolated from liquid cultures of , a plant-associated bacterium. These compounds were purified using Amberlite XAD-2 and reverse-phase liquid chromatography. Pseudomycin A, the predominant peptide in a family of four, showed selective phytotoxicity, and had impressive activity against the human pathogen . Amino acid, mass spectroscopic, and comparative electrophoretic and chromatographic analyses revealed that the pseudomycins are different from previously described antimycotics from . , including syringomycin, syringotoxin and syringostatins. Pseudomycins A–C contain hydroxyaspartic acid, aspartic acid, serine, arginine, lysine and diaminobutyric acid. The molecular masses of pseudomycins A–C, as determined by plasma desorption mass spectrometry, are 1224,1208 and 1252 Da, respectively. Pseudomycin D, on the other hand, has a molecular mass of 2401 Da and is more complex than pseudomycins A–C.

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1991-12-01
2021-05-06
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