1887

Abstract

Summary: The effects of subminimal inhibitory concentrations (subMICs) of certain antibiotics, namely penicillin G, tetracycline and trimethoprim/sulphamethoxazole, on the growth and morphology of were evaluated. SubMICs of penicillin markedly reduced the growth of Tetracycline and trimethoprim/ sulphamethoxazole had no effect on its growth. SubMICs of penicillin greatly affected the morphology of At the highest concentrations tested (1/2 and 1/4 MIC) cells were acapsulate, and long filamentous cells (4–6 μm) were observed with some isolates. There was no correlation between the observed differences in the penicillin-binding proteins of the isolates, and the extent of cell filamentation induced by penicillin G. SubMICs of tetracycline and trimethoprim/sulphamethoxazole did not seem to affect capsule production although filamentation was observed. Our results indicate that subMICs of penicillin can reduce growth of Furthermore, results also indicate that subMICs of antibiotics can affect the production of capsular material and the morphology of

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1991-11-01
2021-04-19
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