1887

Abstract

Summary: A mutant () of resistant to the polyene antibiotic nystatin was compared with its sensitive, wild-type parent to detect differences in sterol composition using gas chromatography—mass spectrometry. The major sterol in wild-type mycelia, comprising 80% of the total, was ergosterol. The major sterols in mutant mycelia, comprising 86% of the total, were δ814-sterols. It is proposed that the nystatin-resistant strain is unable to synthesize ergosterol because it lacks δ1415-reductase activity as a result of a mutation in the gene.

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/content/journal/micro/10.1099/00221287-137-11-2627
1991-11-01
2019-11-19
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-137-11-2627
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