is a bacterium which is part of the normal flora of the human upper respiratory tract and is an occasional cause of disease. Using a previously cloned type 4 pilin gene () from as a hybridization probe, we have cloned an 826 bp 3AI fragment which contains an type 4 pilin gene () from strain NCTC 7784. The pilin gene is expressed in . We have examined NCTC 7784 and nine other strains by genomic Southern hybridization using as a probe, and they all appeared to have more than one pilin gene. While the predicted amino acid sequence of the pilin has conserved regions as compared to pilins of and , it also shows similarities to both the type 4 pilin of and the type 4 pilin of (formerly ).


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