1887

Abstract

Genes encoding extracellular -lactamases of and were cloned and mapped in . DNA sequence analysis of the -lactamase genes revealed a high overall G + C content, ranging from 71 to 75 mol%, with a G + C content of 95 mol % at the third position of the codons for all four genes. The primary structure of the -lactamases including their signal peptides was deduced. The four -lactamases exhibited homology to each other and to class A -lactamases from other bacterial genera. We suggest that -lactamases are representatives of a superfamily of genes, from which class A -lactamases of Gram-negative bacteria may have evolved.

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1990-03-01
2022-01-28
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