1887

Abstract

Human luteinizing hormone (hLH) and the GTP analogue guanosine 5′--(3-thio)triphosphate stimulated morphogenesis in the dimorphic fungal pathogen . hLH bound specifically to subcellular fractions from and stimulated adenylate cyclase activity in microsomes. We provide the first demonstration of guanine-nucleotide-binding proteins (G-proteins) in , and propose that the stimulation of morphogenesis by hLH is mediated by a receptor-coupled adenylate cyclase system involving G-proteins.

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1990-11-01
2024-12-08
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References

  1. Adams D. J., Seilman S., Amelizad Z., Oesch F., Wolf C. R. 1985; Identification of human cytochromes P-450 analogous to forms induced by phenobarbital and 3-methylcholanthrene in the rat. Biochemical Journal 232:869–876
    [Google Scholar]
  2. Bhullar R. P., Haslam R. J. 1987; Detection of 23–27 kDa GTP-binding proteins in platelets and other cells. Biochemical Journal 245:617–620
    [Google Scholar]
  3. Bramley T. A. 1981; Properties of LH/hCG receptors in porcine corpus luteum homogenates and subcellular fractions and factors influencing the recovery of membrane-bound hormone. Molecular and Cellular Endocrinology 24:29–40
    [Google Scholar]
  4. Bramley T. A., Menzies G. S., Williams R. J., Adams D. J., Kinsman O. S. 1990; Specific, high affinity binding sites for human luteinizing hormone [hLH] and human chorionic gonadotrophin [hCG] in Candida species. Biochemical and Biophysical Research Communications 167:1050–1056
    [Google Scholar]
  5. Comerford J. G., Dawson A. P. 1989; The effect of limited proteolysis on GTP-dependent Ca2+ efflux and GTP-dependent fusion in rat liver microsomal vesicles. Biochemical Journal 258:823–829
    [Google Scholar]
  6. Egidy G., Paveto C., Passeron S., Galvagno M. A. 1990; cAMP levels and in situ measurement of cAMP related enzymes during yeast-to-hyphae transition in Candida albicans . Cell Biology International Reports 14:59–65
    [Google Scholar]
  7. Engelberg D., Perlman R., Levitzki A. 1989; Transmembrane signalling in Saccharomyces cerevisiae . Cellular Signalling 1:1–7
    [Google Scholar]
  8. Gilman A. G. 1984; G-proteins and dual control of adenylate cyclase. Cell 36:577–579
    [Google Scholar]
  9. Hunzicker-Dunn M., Birnbaumer L. 1985; The involvement of adenylyl cyclase and cyclic AMP dependent protein kinases in luteinizing hormone actions. In Luteinizing Hormone Action and Receptors pp. 57–134 Ascoli M. Edited by Boca Raton, Florida: CRC Press Inc;
    [Google Scholar]
  10. Kinsman O. S., Pitblado K., Coulson C. J. 1988; Effect of mammalian steroid hormones and luteinizing hormone on the germination of Candida albicans and implications for vaginal candidosis. Mycoses 31:617–626
    [Google Scholar]
  11. Lapetina E. G., Reep B. R. 1987; Specific binding of [α−32P]GTP to cytosolic and membrane bound proteins of human platelets correlates with the activation of phospholipase C. Proceedings of the National Academy of Sciences of the United States of America 84:2261–2265
    [Google Scholar]
  12. Lee K. L., Buckley H. R., Campbell C. C. 1975; An amino acid synthetic medium for the development of mycelial and yeast forms of Candida albicans . Sabouraudia 13:148–153
    [Google Scholar]
  13. Liao H., Thorner J. 1980; Yeast mating pheromone inhibits adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America 77:1898–1902
    [Google Scholar]
  14. Matsumoto K., Nakafuku M., Nakayama N., Miyajima I., Kaibuchi K., Miyajima A., Brenner C., Arai K., Kaziro Y. 1988; The role of G proteins in yeast signal transduction. Cold Spring Harbor Symposia on Quantitative Biology 53:567–575
    [Google Scholar]
  15. Morgan N. G. 1989; Guanine-nucleotide binding proteins as signal transducers. In Cell Signalling pp. 35–57 Milton Keynes: Open University Press;
    [Google Scholar]
  16. Novick P. J., Goud B., Salminen A., Walworth N. C., Nair J., Potenza M. 1988; Regulation of vesicular traffic by a GTP-binding protein on the cytoplasmic surface of secretory vesicles in yeast. Cold Spring Harbor Symposia on Quantitative Biology 53:637–647
    [Google Scholar]
  17. Pace U., Hanski E., Salomon Y., Lancet D. 1985; Odorant-sensitive cyclase may mediate olfactory reception. Nature; London: 316255–258
    [Google Scholar]
  18. Rodbell M. 1980; The role of hormone receptors and GTP-regulatory proteins in membrane transduction. Nature; London: 28417–22
    [Google Scholar]
  19. Salomon Y., Londos C., Rodbell M. 1974; A highly sensitive adenylate cyclase assay. Analytical Biochemistry 58:541–548
    [Google Scholar]
  20. Schramm M., Selinger Z. 1984; Message transmission: receptor controlled adenylate cyclase system. Science 225:1350–1356
    [Google Scholar]
  21. Soll D. R. 1985 Candida albicans. In Fungal Dimorphism. With Emphasis on Fungi Pathogenic for Humans pp. 167–195 Szaniszlo P. J. Edited by New York: Plenum Press;
    [Google Scholar]
  22. Wigler M., Field J., Powers S., Broek D., Toda T., Cameron S., Nikawa J., Michaeli T., Colicelli J., Ferguson K. 1988; Studies of RAS function in the yeast Saccharomyces cerevisiae . Cold Spring Harbor Symposia on Quantitative Biology 53:649–655
    [Google Scholar]
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