1887

Abstract

Human luteinizing hormone (hLH) and the GTP analogue guanosine 5′--(3-thio)triphosphate stimulated morphogenesis in the dimorphic fungal pathogen . hLH bound specifically to subcellular fractions from and stimulated adenylate cyclase activity in microsomes. We provide the first demonstration of guanine-nucleotide-binding proteins (G-proteins) in , and propose that the stimulation of morphogenesis by hLH is mediated by a receptor-coupled adenylate cyclase system involving G-proteins.

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1990-11-01
2021-05-17
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