1887

Abstract

Summary: Hyphal development in was selectively blocked by the ornithine decarboxylase competitive inhibitor 1,4-diaminobutanone (DAB). Inhibition of hyphal development required DAB during both yeast inoculum growth and subsequent incubation at 37°C to induce mycelial growth. This effect was not due to general growth inhibition since DAB did not inhibit yeast growth, and reduced protein synthesis by 30% at most. Moreover, protein synthesis was unaffected by DAB when cells were pre-grown in drug-containing media. Since DAB inhibited dimorphic transition at 37°C, morphology- and temperature-dependent protein synthesis could be distinguished. DAB stimulated the synthesis of several yeast wall-proteins, irrespective of morphology or growth temperature, and two at 37°C only, but it inhibited the synthesis of a single mycelial-specific glycoprotein species.

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/content/journal/micro/10.1099/00221287-136-10-1937
1990-10-01
2019-10-15
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-136-10-1937
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