SUMMARY: The relationship between the release of fructose from 01 lipopolysaccharides (LPS) by dilute acetic acid hydrolysis and the decrease in their antigenicity was examined. Decrease in the intigenicity of LPS was not parallel with the release of fructose, and occurred very much later than the latter. Periodate oxidation of LPS resulted in the total elimination of the fructose and glucose, and two-thirds of the heptose constituents, but no difference in the antigenicity of LPS was observed before and after oxidation. These findings indicate that the fructose present in O1 LPS is not substantially involved in their specific antigenicity. In the O1 LPS, the fructose is in the branch structure, most probably in the core region.


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