1887

Abstract

Incubation of pneumococci with -alanine-containing peptides naturally occurrins in peptidoglycan protected cells against lysis and killing by -lactam antibiotics near MIC. Such peptides caused decreased binding of the antibiotic to penicillin-binding proteins (PBPs), primarily PBP 2B. This provides direct evidence for the hypothesis that -lactams act as substrate analogues and identifies PBP 2B as a killing target in pneumococci.

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/content/journal/micro/10.1099/00221287-135-3-639
1989-03-01
2022-01-25
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