1887

Abstract

SUMMARY: Incubation of pneumococci with -alanine-containing peptides naturally occurrins in peptidoglycan protected cells against lysis and killing by β-lactam antibiotics near MIC. Such peptides caused decreased binding of the antibiotic to penicillin-binding proteins (PBPs), primarily PBP 2B. This provides direct evidence for the hypothesis that β-lactams act as substrate analogues and identifies PBP 2B as a killing target in pneumococci.

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/content/journal/micro/10.1099/00221287-135-3-639
1989-03-01
2019-11-13
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-135-3-639
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