1887

Abstract

TK21 possesses inducible ribosomal RNA methylase activity that confers high-level resistance to lincomycin and lower levels of resistance to certain macrolides. The methylase gene (designated ) is inducible by erythromycin and other macrolides and also by celesticetin (a lincosamide) but not by lincomycin. The enzyme monomethylates the -amino group of adenosine at position 2058 within 23S-like ribosomal RNA.

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/content/journal/micro/10.1099/00221287-135-12-3281
1989-12-01
2022-01-19
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