Summary: Tetracycline (Tc) resistance was found in nine out of ten clinical isolates of Conjugative transposons, designated Tn, Tn and Tn, were present in the chromosome of three isolates. The transposons were similar both structurally and functionally to Tn containing the determinant. A large non-conjugative plasmid found in a fourth isolate contained an element homologous to Tn. The four isolates containing the element showing homology to Tn exhibited a substantially higher level of Tc resistance than the remaining five Tc-resistant isolates. Tc-resistance genes which have not been identified are apparently responsible for the low-level Tc resistance in five clinical isolates.


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