Summary: Carbon catabolite repression was studied in secreted (invertase) and mitochondrial (isocitrate dehydrogenase) enzymes Both enzymes were subject to repression by glucose when the fungus was grown at pH 4·5. Repression of invertase but not of isocitrate dehydrogenase was overcome when xylose was added to the growth medium together with glucose. Derepression of invertase activity was obtained when the fungus was grown in a medium with glucose and at pH 7·3. This pH-dependent derepression was not due to enzyme redistribution or stimulation of activity. In contrast, isocitrate dehydrogenase activity was not derepressed at pH 7·3, but was significantly reduced either in the presence or absence of glucose.


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