1887

Abstract

A monoclonal antibody (mAb) was prepared by hybridoma technology in BALB/c mice immunized to serovar . This mAb agglutinated serovars and to high titres and protected hamsters, dogs and monkeys against challenge with a virulent strain of serovar . The mAb gave protection to hamsters at dilutions up to 1 in 1000; at a 1 in 10 dilution the protective effect lasted for at least two weeks. Biochemical analysis by SDS-PAGE and Western blotting indicated that this mAb reacred with an epitope of a carbohydrate nature.

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1989-01-01
2022-01-17
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