1887

Abstract

SUMMARY: Evidence is presented for a new pathway of acetone metabolism in . The initial step involves a carboxylation, probably resulting in the formation of acetoacetate. Cells grown on acetone and propan-2-ol fixed large quantities of CO, in contrast to cells grown on acetate and acetoacetate. Growth on acetone and propan-2-ol, but not on other substrates, was dependent on the exogenous supply of CO. NMR studies on the labelling pattern of the intracellular poly-β-hydroxybutyrate (PHB) confirmed that C units are produced from acetone after initial carboxylation. The metabolism of acetone and propan-2-ol was associated with drastic changes in the ultrastructure of the organisms. During growth on these substrates, proteinaceous, crystalline inclusions were observed. These were absent in acetate-grown cells. The nature of these crystalline inclusions remains to be elucidated.

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/content/journal/micro/10.1099/00221287-134-8-2281
1988-08-01
2019-11-22
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-134-8-2281
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